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Warfarin embryopathy.

Kiat Yeong Chan1, Enid Gilbert-Barness, George Tiller

  • 1University of South Florida School of Medicine, Tampa, Florida, USA.

Pediatric Pathology & Molecular Medicine
|December 25, 2003
PubMed
Summary
This summary is machine-generated.

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Warfarin embryopathy, a condition caused by prenatal warfarin exposure, can lead to severe congenital abnormalities. This case highlights the risks of anticoagulation therapy during pregnancy, resulting in multiple fetal malformations.

Area of Science:

  • Teratology
  • Obstetrics
  • Pediatric Cardiology

Background:

  • Prophylactic anticoagulation therapy is sometimes necessary during pregnancy, but carries potential risks.
  • Warfarin, a common anticoagulant, is known to cross the placenta and can cause fetal harm.
  • Maternal pulmonary emboli necessitated anticoagulation in this case.

Observation:

  • A pregnancy complicated by maternal pulmonary emboli was managed with anticoagulation.
  • Ultrasound revealed fetal hydrocephalus and cardiac defects at 25 weeks' gestation.
  • The pregnancy was terminated due to these findings.

Findings:

  • The fetus exhibited multiple congenital abnormalities including nasal hypoplasia, earfold atresia, bilobed lungs, coarctation of the aorta, ventricular septal defect, gastroschisis, and skeletal stippling.

Related Experiment Videos

  • These physical and radiological findings are characteristic of warfarin embryopathy.
  • The constellation of anomalies strongly suggests prenatal exposure to warfarin.

    • Implications:

    • This case underscores the teratogenic potential of warfarin during pregnancy.
    • Careful risk-benefit assessment is crucial when considering anticoagulation in pregnant patients.
    • Awareness of warfarin embryopathy is vital for obstetricians, radiologists, and neonatologists.