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[Time-effect and dose-effect relationships study on the effect of benefiting-bone capsule on osteoblasts
Xiaochun Shu1, Ronghua Zhang, Keping Peng
1Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000.
Objective:
To investigate the effect of rats sera containing Benefiting-bone Capsule (BBC) on the cell proliferation of skull osteoblast in neonatal SD rats.
Methods:
Forty female SD rats, aged 12 months, were randomly divided into 4 groups including N.S. group, low dosage, middle dosage and high dosage BBC group, the sera were obtained at different times. MTT method was used to determine the effect of BBC on osteoblasts proliferation.
Results:
The MTT value reached its highest point 1.5 hours after oral administration (P < 0.05). MTT of high dosage BBC met the maximum value with the concentration of 25% (P < 0.05).
Conclusions:
The rats sera containing BBC can promote proliferation of osteoblast.