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Updated: Aug 29, 2026

Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages
Published on: February 22, 2017
[Antimicrobial activity of hinokitiol against Legionella pneumophila]
Sumiyo Ishimatsu1, Yuki Ohga, Tohru Ishidao
1Department of Environmental Management I, School of Health Sciences, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Abstract:
Antimicrobial activity of hinokitiol (beta-thujaplicin), which is a major component of the essential oil of Chamaecyparis obtuse, against Legionella pneumophila was investigated experimentally. The quantitative antibacterial assay of hinokitiol was carried out by the disk-diffusion method. The test concentrations of hinokitiol were 0.39 to 25.0 micrograms/disk, and the lowest concentrations of hinokitiol that showed growth inhibition against L. pneumophila were 1.56 micrograms/disk on B-SYE agar and 0.39 microgram/disk on B-SYE agar without iron.
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