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Postprandial acid reflux is reduced by delayed gastric emptying
Yoshinori Yamashita1, Rodney J Mason, Tom R Demeester
1Department of Surgery, Hiroshima City Asa Hospital, Hiroshima, Japan. yosy.811kob@k3.dion.ne.jp
Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi
|December 25, 2003
Summary
Delayed gastric emptying does not directly correlate with postprandial reflux. However, abnormal acid exposure with normal reflux may indicate delayed gastric emptying in patients undergoing esophageal pH monitoring.
Area of Science:
- Gastroenterology
- Digestive Physiology
Background:
- Gastroesophageal reflux disease (GERD) is a common condition.
- The relationship between gastric emptying and postprandial reflux is not fully understood.
Purpose of the Study:
- To investigate the influence of delayed gastric emptying on postprandial reflux.
- To analyze esophageal pH monitoring and gastric emptying in patients.
Main Methods:
- Sixty-nine patients underwent 24-hour esophageal pH monitoring and gastric emptying studies.
- Gastric emptying was measured using a gamma detector after a solid test meal.
- % postprandial reflux (PRT) was calculated from the pH monitoring data.
Main Results:
- % PRT was similar across normal, delayed, and rapid gastric emptying groups.
- Patients with normal gastric emptying had higher % PRT than delayed emptying in the positive pH study group.
- Delayed gastric emptying was more prevalent in patients with normal % PRT but abnormal acid exposure.
Conclusions:
- Delayed gastric emptying may be associated with abnormal acid exposure despite normal % PRT.
- The findings suggest a complex interplay between gastric emptying and esophageal acid reflux.
- Further research is needed to elucidate the precise mechanisms involved.