Related Experiment Videos
Superficial leiomyosarcoma treated with Mohs micrographic surgery.
Tatyana R Humphreys1, David H Finkelstein, Jason B Lee
1Department of Dermatology, Division of Cutaneous Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. tatyana.humphreys@mail.tju.edu
Summary
Mohs micrographic surgery (MMS) offers an 87% cure rate for cutaneous leiomyosarcoma (LMS), significantly reducing recurrence compared to wide excision. This tissue-sparing technique is a promising treatment for this rare cancer.
Area of Science:
- Dermatology
- Surgical Oncology
- Oncology
Background:
- Cutaneous leiomyosarcoma (LMS) is a rare malignancy with a high recurrence rate (30-45%) after conventional wide excision.
- The infiltrative growth pattern of LMS poses challenges for complete surgical removal.
Observation:
- This study presents three cases of LMS managed with Mohs micrographic surgery (MMS).
- Clinical presentations varied, with one case in an immunosuppressed patient showing aggressive behavior and deep invasion.
Findings:
- MMS achieved a 13% recurrence rate in a total of 15 reported cases, including the three presented.
- An overall cure rate of 87% was observed for LMS treated with MMS.
Implications:
- MMS provides a favorable cure rate and tissue-sparing advantage over traditional wide excision for cutaneous LMS.
- Immunosuppression may be a risk factor for aggressive LMS, and deeply invasive tumors can metastasize regardless of surgical technique.