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Updated: Jun 7, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete
09:45

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete

Published on: January 24, 2025

When secondary syphilis is reliably recognizable.

Jordan T Hyde1, Jason B Lee1

  • 1Department of Dermatology & Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.

Journal of the American Academy of Dermatology
|June 5, 2026
PubMed
Summary
This summary is machine-generated.

Condyloma lata, a secondary syphilis manifestation, has distinct histopathologic features identifiable on routine stains. Recognizing these patterns aids pathologists in accurate diagnosis and avoids misinterpretation as cancer.

Keywords:
condyloma lataextragenital condyloma lataextragenital syphilissecondary syphilissquamous cell carcinomasyphilistreponema pallidumverrucous carcinoma

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Area of Science:

  • Dermatopathology
  • Infectious Diseases
  • Histopathology

Background:

  • Syphilis, caused by Treponema pallidum, is a complex infection with varied presentations.
  • Secondary syphilis can manifest as condyloma lata, posing diagnostic challenges due to its mimicry.
  • Histopathologic identification of condyloma lata is crucial for accurate diagnosis.

Purpose of the Study:

  • To describe the characteristic histopathologic features of condyloma lata.
  • To highlight the diagnostic value of these features on routine hematoxylin and eosin staining.
  • To aid pathologists in differentiating condyloma lata from other conditions, including malignancy.

Main Methods:

  • Retrospective analysis of 15 histopathologic cases diagnosed as condyloma lata.
  • Evaluation of characteristic findings on hematoxylin and eosin stained slides.
  • Correlation of histopathologic features with clinical context when available.

Main Results:

  • Condyloma lata consistently showed pseudoepitheliomatous hyperplasia.
  • A dense or lichenoid lymphoplasmacytic infiltrate was a common finding.
  • Prominent neutrophilic exocytosis, epithelial erosion with neutrophils, and spongiotic vesicles were observed.

Conclusions:

  • Condyloma lata exhibits a reproducible and diagnostically valuable histopathologic pattern.
  • These features are identifiable on routine hematoxylin and eosin stains.
  • Familiarity with this pattern improves diagnostic accuracy and prevents misdiagnosis, especially in challenging cases.