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A cross-sectional study evaluating post-thrombotic syndrome in children
Stefan Kuhle1, Barbara Koloshuk, Velma Marzinotto
1Department of Population Health Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada.
Thrombosis Research
|December 25, 2003
Summary
Post-thrombotic syndrome (PTS) significantly affects children after deep vein thrombosis (DVT). Key risk factors include incomplete DVT resolution and the number of vessels affected, highlighting the need for pediatric DVT monitoring.
Area of Science:
- Pediatric vascular health
- Clinical outcomes of thrombosis
- Long-term sequelae of deep vein thrombosis
Background:
- Post-thrombotic syndrome (PTS) is a complication of deep vein thrombosis (DVT), causing limb swelling, pain, and skin changes.
- While well-documented in adults, the incidence and characteristics of PTS in pediatric populations remain understudied.
Purpose of the Study:
- To investigate the incidence and clinical presentation of PTS in children.
- To identify predictors associated with PTS development in pediatric patients following DVT.
Main Methods:
- A cross-sectional study involving 153 children with confirmed DVT.
- Standardized PTS scoring was used to classify severity (absent, mild, moderate, severe).
Main Results:
- PTS was observed in 63% of children, predominantly mild (83%) or moderate (17%).
- Common symptoms included limb swelling; objective signs were increased limb circumference and collateral circulation.
- Predictors of PTS included lack of DVT resolution (OR 3.96), number of affected vessels (OR 2.05), and follow-up duration (OR 1.22).
Conclusions:
- Post-thrombotic syndrome is a significant clinical issue in children with a history of DVT.
- Early identification of risk factors may aid in managing and potentially preventing PTS in pediatric patients.