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CDK2 and cyclin E knockout mice: lessons from breast cancer

Nathan H Lents1, Joseph J Baldassare

  • 1Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA. lentsnh@slu.edu

Trends in Endocrinology and Metabolism: TEM
|December 25, 2003
PubMed
Summary

Cyclin E-CDK2 is not essential for embryonic development, yet its abnormal expression is linked to breast cancer progression and poor prognosis. This highlights a complex role in cell division and disease.

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