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[A clinical study on delayed encephalopathy after carbon monoxide poisoning]
Hai Yu1, Xiaowen Pan, Juan Meng
1Department of Hyperbaric Oxygen, PLA Naval General Hospital, Beijing 100037, China.
Objective:
To investigate clinical and imaging characteristics of delayed encephalopathy after carbon monoxide poisoning(DEACMP).
Methods:
A retrospective and comparative analysis of neurological manifestations, course, periods of false-cure, prognosis and neuroimaging findings were conducted in 198 patients with DEACMP.
Results:
Of these patients, 60.1% obtained an initial recovery within 30 d, 23.7% within 31-60 d and 14.6% over 60 d. Total clinical rate was 32.8%, and effectiveness rate 70.1%. According to imaging findings, 15.2% patients were found to have bilateral lesions of basal ganglion, and 70.0% with lesions of subcortical white matter, 12.6% with lesions of two types above mentioned and 2.1% with no lesions. The intervals between onset of illness and initial recovery were (44.6 +/- 10.1), (38.2 +/- 11.9), (61.3 +/- 17.0) d, and (7.5 +/- 2.4) d respectively. Imaging findings can demonstrate the severity of brain injury, but not necessarily parallel to the improvement of illness, for which SPECT proves more useful.
Conclusions:
DEACMP is involved in ischemic brain injury and a self-limited illness.