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Manipulation of cell surface macromolecules by flaviviruses.
1Department of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, B3H 4H7 Canada.
Advances in Virus Research
|December 31, 2003
Summary
Cell surface molecules are key to flavivirus infections, acting as entry receptors and influencing inflammation. Understanding these interactions is vital for flavivirus pathogenesis research.
Area of Science:
- Virology
- Immunology
- Cell Biology
Background:
- Cell surface macromolecules are critical in flavivirus biology and disease.
- They mediate virus entry and modulate cellular processes like inflammation and vascular permeability.
Purpose of the Study:
- To review flavivirus cell tropism and pathogenesis.
- To examine the role of cell surface molecules in virus-cell and cell-cell interactions.
Main Methods:
- Literature review of studies on flavivirus-host interactions.
- Analysis of the involvement of cell surface molecules in flavivirus infection.
Main Results:
- Cell surface molecules function as receptors for flavivirus entry.
- These molecules also mediate cell-cell interactions, influencing vascular permeability and inflammation.
- A complex interplay exists between the virus, immune complexes, Fc receptors, MHC antigens, and adhesion molecules.
Conclusions:
- Cell surface molecules are central to flavivirus pathogenesis.
- Further research into these interactions can reveal therapeutic targets.