Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Crohn's disease & aflatoxins.

R N Roy¹, R I Russell

¹Faculty of Health Studies, Queen's College, Glasgow.

Journal of the Royal Society of Health

|December 1, 1992

Summary

This study explored the link between Crohn's disease and aflatoxins, toxic food metabolites. Some patients with Crohn's disease and other gastrointestinal disorders showed evidence of aflatoxins in their system.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Assessment of individual and dyadic workload of student and instructor pilots in real and simulated flight: An exploratory study.

Applied ergonomics·2025

Same author

Inattentional deafness to auditory alarms: Inter-individual differences, electrophysiological signature and single trial classification.

Behavioural brain research·2018

Same author

Neurosurgery as it was.

Neurology India·2018

Same author

A Case of Chloramphenicol Resistant Primary Syphilis Treated with Penicillin.

Indian journal of dermatology and venereology·2017

Same author

A Case of Bacillary Dysentery Simulating Acute Abdominal Catastrophy in Its Early Stages.

The Indian medical gazette·2017

Same author

Efficient mental workload estimation using task-independent EEG features.

Journal of neural engineering·2016

Area of Science:

Gastroenterology
Toxicology
Food Science

Background:

Crohn's disease is a chronic inflammatory bowel condition.
Aflatoxins are toxic and carcinogenic metabolites found in food.
The potential link between aflatoxins and inflammatory bowel diseases is not well understood.

Purpose of the Study:

To investigate the presence of aflatoxins in patients with Crohn's disease.
To explore potential correlations between aflatoxins and other gastrointestinal disorders.
To examine possible sources of aflatoxin exposure or impaired excretion in affected patients.

Main Methods:

Qualitative and quantitative analysis of serum and urine samples.
Techniques used included thin layer chromatography, the Aflatest method, and fluorimetry.
Study involved 24 patients diagnosed with Crohn's disease, coeliac disease, or ulcerative colitis.

Main Results:

Evidence of varying amounts of aflatoxins detected in the serum and urine of some patients.
The presence of aflatoxins was observed in patients with Crohn's disease, coeliac disease, and ulcerative colitis.
Findings suggest potential exposure to contaminated food or impaired aflatoxin excretion due to gastrointestinal issues.

Conclusions:

A potential association between aflatoxins and inflammatory bowel diseases like Crohn's disease is suggested.
Further long-term research is required to establish a definitive link.
Investigating dietary history and aflatoxin excretion capacity is crucial for future studies.

Related Experiment Videos