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Published on: February 14, 2011
Cutaneous histoplasmosis in patients with acquired immunodeficiency syndrome
Joshua David Rosenberg1, Noah S Scheinfeld
1Albert Einstein College of Medicine, Bronx, New York, USA.
Abstract:
Since 1987, the US Centers for Disease Control and Prevention has considered disseminated histoplasmosis an acquired immunodeficiency syndrome (AIDS)-defining illness. Cutaneous manifestations of disseminated disease are diverse and often present as a nondescript rash with systemic complaints. Diagnosis is best established by histopathologic examination with appropriate stains for fungal organisms. Skin lesions often resolve within weeks of initiating treatment. We detail a case of cutaneous histoplasmosis and review its epidemiology, common presentations, diagnosis, and treatment options.
Insights
Disseminated histoplasmosis, an AIDS-defining illness, can cause diverse skin rashes. Early diagnosis via histopathology and prompt treatment lead to rapid skin lesion resolution.
Area of Science:
- Mycology
- Infectious Diseases
- Dermatology
Background:
- Disseminated histoplasmosis is an AIDS-defining illness per the CDC since 1987.
- Cutaneous manifestations are common but often nonspecific, presenting as rashes with systemic symptoms.
Observation:
- A case of cutaneous histoplasmosis is presented.
- The diverse and often nondescript nature of skin lesions in disseminated histoplasmosis is highlighted.
Findings:
- Histopathologic examination with fungal stains is the gold standard for diagnosis.
- Skin lesions typically resolve quickly following treatment initiation.
Implications:
- Understanding the varied cutaneous presentations is crucial for timely diagnosis.
- Effective treatment options exist for cutaneous histoplasmosis, leading to favorable outcomes.
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