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Bilateral keratoconjunctivitis associated with lichen planus.

Michelle K Rhee1, V Vinod Mootha

  • 1Eye and Ear Institute of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.

Cornea
|January 1, 2004
PubMed
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Lichen planus can cause severe eye inflammation, known as keratoconjunctivitis. This case report highlights successful treatment using oral prednisone, topical cyclosporine, and amniotic membrane transplantation for this rare ocular complication.

Area of Science:

  • Ophthalmology
  • Dermatology
  • Immunology

Background:

  • Lichen planus is a chronic inflammatory condition affecting skin and mucous membranes.
  • Ocular involvement in lichen planus, particularly keratoconjunctivitis, is rare but can lead to significant visual impairment.
  • Understanding the pathogenesis and treatment of ocular lichen planus is crucial for patient management.

Purpose of the Study:

  • To report a case of bilateral keratoconjunctivitis in a patient diagnosed with lichen planus.
  • To review the existing literature on ocular manifestations of lichen planus.
  • To discuss potential therapeutic strategies for lichen planus-associated keratoconjunctivitis.

Main Methods:

  • A case report of a 33-year-old male with lichen planus and recurrent keratoconjunctivitis.

Related Experiment Videos

  • Review of English-language literature on lichen planus and keratoconjunctivitis.
  • Documentation of treatment responses to various topical and systemic medications.

    • Main Results:

    • This represents the fourth reported case of keratoconjunctivitis associated with lichen planus.
    • The patient experienced recurrent, progressive keratoconjunctivitis unresponsive to initial topical treatments.
    • A combination of tapered oral prednisone, 2% topical cyclosporine, and amniotic membrane transplantation effectively managed the acute exacerbation.

    Conclusions:

    • Lichen planus can lead to severe ocular surface disease, including cicatricial conjunctivitis, keratouveitis, and corneal ulceration.
    • Amniotic membrane transplantation may serve as an adjunctive therapy for refractory lichen planus-related keratoconjunctivitis.
    • Topical cyclosporine, in conjunction with systemic immunosuppression, can help stabilize the ocular surface in severe cases.