Related Experiment Video
Updated: Aug 29, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
Published on: July 27, 2022
Overview of radiation- and chemoradiation-induced diarrhea
1Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, FL, USA.
Objectives:
To describe the pathophysiology, incidence, and impact of radiation-induced diarrhea (RID), and to highlight the radiation oncology nurse's role.
Data Sources:
Primary and tertiary literature, and clinical experience.
Conclusion:
RID is a frequent complication of pelvic radiation, both when given alone and with chemotherapy. RID can significantly affect patient quality of life. Since diarrhea may be a difficult topic for patients to discuss, special care needs to be taken to avoid underdiagnosis of this problem.
Implications For Nursing Practice:
The oncology nurse is uniquely situated to monitor patients for the development of RID, assess its severity and provide guidance to the health care team on the patient's status.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
Adsorbents...
