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Updated: Aug 29, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Spiculoic acids A and B, new polyketides isolated from the Caribbean marine sponge Plakortis angulospiculatus
Xin-Hui Huang1, Rob van Soest, Michel Roberge
1Departments of Chemistry, Earth & Ocean Sciences, University of British Columbia, Vancouver, BC V6T 1Z1.
Abstract:
[structure: see text] Two novel polyketides, spiculoic acids A (1) and B (2), have been isolated from extracts of the Caribbean marine sponge Plakortisangulospiculatus. The structures of 1 and 2 were elucidated by detailed analysis of spectroscopic data. Spiculoic acid A (1) showed in vitro cytotoxicity against human breast cancer MCF-7 cells. It has a putative polyketide biogenetic origin that involves incorporation of four butyrate units and a Diels Alderase catalyzed intramolecular [4 + 2] cycloaddition reaction.
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