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Endothelial dysfunction and alteration of nitric oxide/ cyclic GMP pathway in patients with exercise-induced

Hyuk Jae Chang1, Jae Hoon Chung, Byoung Joo Choi

  • 1Dr. Hyuk-Jae Chang, Department of Cardiology, Ajou University School of Medicine, San 5 Won chon-dong, Paldal-gu, Suwon 442-721, Korea. hjchang70@hotmail.com

Yonsei Medical Journal
|January 3, 2004
PubMed

Insights

Exercise-induced hypertension is linked to impaired endothelial function and nitric oxide pathway dysfunction. This suggests a role for endothelial dysfunction in the cardiovascular risks associated with exercise hypertension.

Area of Science:

  • Cardiovascular Physiology
  • Endothelial Function Research
  • Hypertension Studies

Background:

  • Exaggerated blood pressure response to exercise has unclear diagnostic and prognostic implications.
  • Endothelial dysfunction is a known risk factor for cardiovascular disease, but its role in exercise-induced hypertension is not well understood.

Purpose of the Study:

  • To evaluate endothelial function in individuals with exercise-induced hypertension.
  • To investigate the relationship between endothelial dysfunction and the nitric oxide/cyclic guanosine monophosphate (GMP) pathway in this patient group.

Main Methods:

  • Assessed brachial artery endothelial function using high-resolution ultrasound in 35 patients with exercise-induced hypertension and 35 matched controls.
  • Measured nitric oxide metabolites (NO2-/NO3-) and cyclic GMP levels at rest, during maximal exercise, and during recovery.

Main Results:

  • Endothelial-dependent vasodilation was significantly impaired in patients with exercise-induced hypertension compared to controls.
  • Impaired vasodilation correlated with age and systolic blood pressure difference during exercise.
  • While NO2-/NO3- levels increased similarly in both groups during exercise, cyclic GMP levels were significantly lower in the hypertensive group during maximal exercise.

Conclusions:

  • Patients with exercise-induced hypertension exhibit impaired endothelium-dependent vasodilation.
  • This impairment is associated with a dysfunction in the nitric oxide/cyclic GMP pathway.
  • These findings suggest that endothelial dysfunction may contribute to elevated blood pressure during exercise due to inadequate peripheral vascular adjustment.

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