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[Relations between plasma-erythrocyte viscosity factors and ESR]
A Cortinovis1, A Crippa, M Crippa
1Dipartimento di Medicina Interna e Terapia Medica, Università degli Studi di Pavia.
Minerva Cardioangiologica
|September 1, 1992
Summary
Erythrocyte Sedimentation Rate (ESR) reflects red blood cell (RBC) aggregation and is influenced by plasma factors like fibrinogen. This study explores hemorheological parameters and ESR in inflammatory conditions.
Area of Science:
- Hematology
- Clinical Chemistry
- Biophysics
Background:
- Erythrocyte Sedimentation Rate (ESR) is influenced by red blood cell (RBC) density, plasma viscosity, and RBC surface area.
- RBC aggregation decreases surface area, leading to increased ESR.
- Plasma factors, particularly fibrinogen, significantly impact ESR values.
Purpose of the Study:
- To investigate the relationship between hemorheological parameters and ESR.
- To analyze ESR as an indicator of RBC aggregation in infective and inflammatory processes.
Main Methods:
- Evaluation of plasma viscosity and RBC viscosity.
- Analysis of forces influencing RBC aggregation (attracting, repulsing, shear-stress, surface tension).
- Correlation of hemorheological measurements with ESR in patient cohorts.
Main Results:
- Plasma-RBC viscosity incorporates plasma viscosity and RBC surface area.
- RBC aggregation is a key factor in ESR determination.
- Specific hemorheological parameters show correlations with ESR in inflammatory states.
Conclusions:
- ESR serves as a valuable index for assessing RBC aggregation.
- Understanding hemorheological factors is crucial for interpreting ESR in disease states.
- Further research can elucidate the role of these parameters in infective and inflammatory conditions.