Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sequences associated with human iris pigmentation.

Tony Frudakis1, Matthew Thomas, Zach Gaskin

  • 1DNAPrint Genomics, Sarasota, Florida 34236, USA. tfrudakis@dnaprint.com

Genetics
|January 6, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SynaptoTagMe, a toolkit for in vivo mapping and modulating neurotransmission at single-cell resolution.

eLife·2026
Same author

Lung Dose and Pneumonitis Risk Following Five-Fraction Breast Radiotherapy.

Journal of medical imaging and radiation oncology·2026
Same author

Ventilation strategies and outcomes after out-of-hospital cardiac arrest: protocol for a pre-planned sub-analysis of the STEPCARE trial.

BMJ open·2026
Same author

The Development of Tools to Investigate Potential Sources of Sample Misidentification Within a Biorepository: Case Studies.

Biopreservation and biobanking·2026
Same author

Corrigendum to "Modeling temporal self-continuity and its association with temporal discounting" [Personality and Individual Differences 246 (2025) 113354].

Personality and individual differences·2026
Same author

Acute and chronic allograft dysfunction following pediatric lung transplantation.

JHLT open·2026
Same journal

Adaptive Dynamics of Quantitative Traits in a Steadily Changing Environment.

Genetics·2026
Same journal

Functional Landscape of Zebrafish Gonadotropins and Receptors: A Comprehensive Genetic Analysis.

Genetics·2026
Same journal

Synergistic actions of Nup43 and Myosin VI drive actin cone assembly during Drosophila spermiogenesis.

Genetics·2026
Same journal

Identification of two Cryptococcus neoformans heme transporters involved in Fhb1-mediated nitrosative stress protection in a fission yeast model.

Genetics·2026
Same journal

Analysis of a hypomorphic mei-P26 mutation reveals coordination between developmental programming of germ cells and meiotic chromosome dynamics.

Genetics·2026
Same journal

Neural and Genetic Mechanisms Regulating Copulation Latency in Male Drosophila melanogaster.

Genetics·2026
See all related articles

Common gene variations significantly influence iris color. Researchers identified specific single nucleotide polymorphisms (SNPs), haplotypes, and diplotypes in pigmentation genes linked to diverse iris colors in European populations.

Area of Science:

  • Genetics
  • Human Pigmentation
  • Population Genetics

Background:

  • Iris color variation is a complex human trait.
  • Understanding the genetic basis of iris pigmentation is crucial for population genetics and trait mapping.

Purpose of the Study:

  • To investigate the association between common genetic polymorphisms and natural iris color distributions.
  • To identify specific genes and genomic regions influencing iris pigmentation.

Main Methods:

  • Surveyed 851 individuals of European descent.
  • Analyzed 335 single nucleotide polymorphism (SNP) loci in 13 pigmentation genes and 419 other SNPs.
  • Examined SNPs, haplotypes, and diplotypes for associations with iris color.

Main Results:

Related Experiment Videos

  • Identified significant associations between SNPs, haplotypes, and diplotypes in OCA2, MYO5A, TYRP1, AIM, DCT, TYR, and other genomic regions with iris color.
  • Half of the associated SNPs were on chromosome 15.
  • Multilocus genotypes and diplotypes explained up to 15% of iris color variation.

Conclusions:

  • This study provides a comprehensive candidate gene analysis for iris pigmentation.
  • Results suggest that cryptic population structure can be leveraged for complex trait gene mapping using ancestry informative markers.