Knockout mice in xenobiotic metabolism

Humanization of Drug Metabolism in the Plasmodium berghei Mouse Model for Antimalarial Drug Discovery.

ACS infectious diseases·2025

Application of a mouse model humanized for cytochrome P450-mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs.

Drug metabolism and disposition: the biological fate of chemicals·2025

Integration of in vivo stress reporters with transcription profiling to define chemical mixtures mechanisms of toxicity, including trans-generational effects.

Chemico-biological interactions·2025

AKT/mTOR as a targetable hub to overcome multimodal resistance to EGFR inhibitors in oesophageal squamous cell carcinoma.

British journal of cancer·2025

The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals.

Archives of toxicology·2025

Use of an extensively humanized mouse model to predict the risk of drug-drug interactions in patients receiving dexamethasone.

The Journal of pharmacology and experimental therapeutics·2025

Humanized mouse models for drug metabolism and drug transport: a systematic review.

Drug metabolism reviews·2026

Drug transporters in drug disposition - highlights from the year 2025.

Drug metabolism reviews·2026

Herbal supplements and anti-tuberculosis therapy: unlocking hidden interactions for better multidrug-resistant tuberculosis management.

Drug metabolism reviews·2026

Identification and characterization of a novel aldehyde metabolite of WIN18,446 and associated WIN18,446-ALDH1A2 protein adducts using mass spectrometry.

Drug metabolism reviews·2026

Pharmacomicrobiomics in precision pharmacotherapy: bidirectional microbial-drug interactions as a key determinant of therapeutic response.

Drug metabolism reviews·2026

Population pharmacokinetics of levofloxacin: a systematic review.

Drug metabolism reviews·2026

Identifying the extra nanoparticles from SCR-equipped diesel engines and reducing them via regulating surface tension of aqueous urea solution.

Journal of hazardous materials·2026

Diverse unsaturated fatty acids bypass loss of FabH-catalysed initiation of fatty acid synthesis in Enterococcus faecalis.

Microbiology (Reading, England)·2026

Epigenetic remodeling during UV exposure: high resolution analysis of histone post-translational modifications in a DNA binding protein 2 mutant model.

Histochemistry and cell biology·2026

Diffusion of NiH on Ni(111) and of Ni with Adsorbed H on Ni(111) in the Context of Ni Coarsening in Solid Oxide Cells.

The journal of physical chemistry letters·2026

An Engineered Enzyme Catalyzing Tandem Reductive Aminations for Synthesizing Tertiary Amines.

Angewandte Chemie (International ed. in English)·2026

Origins of Reactivity in SAM-Utilizing Ribozyme SAMURI-Catalyzed RNA Alkylation.

Journal of the American Chemical Society·2026

Related Experiment Videos

Knockout mice in xenobiotic metabolism

Related Concept Videos

Humanization of Drug Metabolism in the Plasmodium berghei Mouse Model for Antimalarial Drug Discovery.

Application of a mouse model humanized for cytochrome P450-mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs.

Integration of in vivo stress reporters with transcription profiling to define chemical mixtures mechanisms of toxicity, including trans-generational effects.

AKT/mTOR as a targetable hub to overcome multimodal resistance to EGFR inhibitors in oesophageal squamous cell carcinoma.

The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals.

Use of an extensively humanized mouse model to predict the risk of drug-drug interactions in patients receiving dexamethasone.

Humanized mouse models for drug metabolism and drug transport: a systematic review.

Drug transporters in drug disposition - highlights from the year 2025.

Herbal supplements and anti-tuberculosis therapy: unlocking hidden interactions for better multidrug-resistant tuberculosis management.

Identification and characterization of a novel aldehyde metabolite of WIN18,446 and associated WIN18,446-ALDH1A2 protein adducts using mass spectrometry.

Pharmacomicrobiomics in precision pharmacotherapy: bidirectional microbial-drug interactions as a key determinant of therapeutic response.

Population pharmacokinetics of levofloxacin: a systematic review.

Identifying the extra nanoparticles from SCR-equipped diesel engines and reducing them via regulating surface tension of aqueous urea solution.

Diverse unsaturated fatty acids bypass loss of FabH-catalysed initiation of fatty acid synthesis in Enterococcus faecalis.

Epigenetic remodeling during UV exposure: high resolution analysis of histone post-translational modifications in a DNA binding protein 2 mutant model.

Diffusion of NiH on Ni(111) and of Ni with Adsorbed H on Ni(111) in the Context of Ni Coarsening in Solid Oxide Cells.

An Engineered Enzyme Catalyzing Tandem Reductive Aminations for Synthesizing Tertiary Amines.

Origins of Reactivity in SAM-Utilizing Ribozyme SAMURI-Catalyzed RNA Alkylation.

Related Experiment Videos

Knockout mice in xenobiotic metabolism

Related Concept Videos

Related Articles