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Updated: Jun 24, 2026

High-Throughput Expression and Purification of Human Solute Carriers for Structural and Biochemical Studies
Published on: September 29, 2023
Drug transporters in drug disposition - highlights from the year 2025
Philip Sandoval1, Pallabi Mitra2, Masanori Nakakariya3
1Takeda Development Center Americas, Inc. (TDCA), Lexington, MA, USA.
Abstract:
On behalf of my co-authors, I am pleased to present our sixth annual review highlighting articles that have been deemed as impactful in the field of drug transporter sciences. Drug transporters influence the absorption, distribution, and elimination of prescribed drugs and, as a result, it is necessary to understand their impact on new drug development programs. The articles highlighted in this review were selected based on their scientific impact, novelty, and relevance to advancing key areas of transporter research, including mechanistic understanding, translational application, and implications for drug development and regulatory science.Similar to our previous reviews, each co-author has selected peer-reviewed articles and provided a brief synopsis of the article and commentary on the article's significance (Chothe et al. 2021,2022,2023,2024; Sandoval et al. 2025). The review is divided into the following sections: (1) transporter function and DDI evaluation, (2) novel in vivo models, (3) endogenous biomarkers, and (4) drug transporter structure and regulation. The following synopses and commentaries are meant to provide high-level highlights of the articles and readers are encouraged to review these articles for further details. While individual studies are discussed within these categories, a key objective of this review is to place these findings within broader emerging trends in transporter sciences. The synopsis and commentaries are therefore intended not only to highlight individual studies but also to provide perspective on how these advances collectively shape the field.
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