Contraction-induced injury run amok: an introduction

Skeletal muscle has an amazing capacity to adapt to increased levels of physical activity. Adaptation is often preceded by contraction-induced injury. In most cases, the damage is repaired quickly, the muscle adapts, and becomes stronger and less fatigable. Diseased or deconditioned muscle is an exception; the response to increased functional demand, and the associated injury can be incomplete or even maladaptive. When and why is an adaptive response limited? This question will be addressed in the symposium papers following this brief introduction. The papers will discuss cellular, molecular, and immunological mechanisms that may be involved in impaired muscle adaptation.