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Primitive neuroectodermal tumor (PNET) of the urinary bladder.

Stefan Krüger1, Hannelore Schmidt, Ingo Kausch

  • 1Institute of Pathology, University of Lübeck, Germany. krueger@patho-mu-luebeck.de

Pathology, Research and Practice
|January 8, 2004
PubMed
Summary

This study details a rare primitive neuroectodermal tumor (PNET) of the urinary bladder in an elderly male. Molecular analysis revealed chromosomal gains, highlighting PNET

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Area of Science:

  • Oncology
  • Uropathology
  • Molecular Cytogenetics

Background:

  • Primitive neuroectodermal tumors (PNETs) are rare malignancies.
  • PNETs primarily occur in the central nervous system, but can arise in extraneural sites, including the urinary bladder.

Observation:

  • An 81-year-old male presented with lower extremity lymphedema, fatigue, and urge incontinence.
  • Radiographic imaging revealed a large bladder tumor extending into pelvic and retroperitoneal tissues.
  • Histological examination showed a small round-cell tumor with high cellularity, necrosis, and mitotic activity.

Findings:

  • Immunohistochemistry demonstrated tumor cell reactivity for neuron-specific enolase (NSE) and CD99 (MIC2 gene product).
  • Electron microscopy identified dense-core granules within tumor cells.

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  • Comparative genomic hybridization (CGH) detected gains in chromosomes 3p, 6, 8q, 12, 17q, and 21q.

    • Implications:

    • This is the fifth reported case of urinary bladder PNET and the first with CGH analysis.
    • The findings contribute to understanding the molecular basis of extraneural PNETs.
    • This case underscores the importance of comprehensive diagnostic evaluation for rare bladder tumors.