Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in pulmonary vascular function after acute methionine loading in normal men.

Conor O'Dochartaigh1, Hean Ong, Sharon Lovell

  • 1Department of Medicine, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, U.K.

Clinical Science (London, England : 1979)
|January 8, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic array data from the Northern Ireland COhort for the Longitudinal study of Ageing (NICOLA).

Research square·2026
Same author

Discovery and characterization of a novel <i>Pseudomonas</i> phage of a new genus.

PHAGE (New Rochelle, N.Y.)·2026
Same author

Food and Water Safety Practices and Preparedness of Ontarians at Home During Power Outages and Other Emergencies: A Cross-Sectional Study.

Journal of food protection·2026
Same author

The "Skipping Rope" Technique: A Novel Strategy for Distal Burr Entrapment During Rotational Atherectomy.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026
Same author

Food Safety Knowledge and Behaviors of Canadians: Foodbook 2.0.

Journal of food protection·2026
Same author

The Impact of Whey and Soy Protein Supplementation on Resistance Training in Young Adults: A Systematic Review and Meta-Analysis.

Journal of dietary supplements·2025
Same journal

Edaravone Dexborneol regulates the endothelial PPARγ-PON1 axis to inhibit high-cholesterol-induced atherosclerosis.

Clinical science (London, England : 1979)·2026
Same journal

HDAC9 promotes atherosclerosis by suppressing CYP7A1 and impairing hepatic cholesterol excretion.

Clinical science (London, England : 1979)·2026
Same journal

Clusterin ameliorates LPS-induced ARDS by inhibiting the Wnt/β-catenin pathway.

Clinical science (London, England : 1979)·2026
Same journal

Human cytomegalovirus at the maternal-fetal interface: an overview of pathogenesis, defence, and interventions.

Clinical science (London, England : 1979)·2026
Same journal

Cardiometabolic regulation by adipocyte-derived leptin and the brain melanocortin system.

Clinical science (London, England : 1979)·2026
Same journal

Impact of impaired branched-chain amino acid metabolism on kidney disease.

Clinical science (London, England : 1979)·2026
See all related articles

Elevated homocysteine (Hcy) levels impair pulmonary circulation, indicated by altered respiratory gas exchange during exercise. This suggests a ventilation/perfusion mismatch due to pulmonary vascular endothelial dysfunction.

Area of Science:

  • Cardiovascular Physiology
  • Pulmonary Medicine
  • Endothelial Function

Background:

  • Elevated homocysteine (Hcy) is linked to endothelial dysfunction in systemic and coronary arteries.
  • The impact of Hcy on pulmonary circulation requires further investigation.

Purpose of the Study:

  • To assess if acute hyperhomocysteinaemia affects pulmonary vascular endothelial function.
  • To investigate changes in cardiopulmonary exercise responses and respiratory gas exchange.

Main Methods:

  • Ten healthy young men underwent cardiopulmonary exercise testing with and without induced hyperhomocysteinaemia via methionine loading.
  • Exhaled nitric oxide (NO), plasma von Willebrand factor (vWf), and factor VIIIc were measured.
  • Respiratory gas exchange parameters, including V(E)/V(CO2) and P(ETCO2), were analyzed.

Related Experiment Videos

Main Results:

  • Methionine loading significantly increased plasma Hcy levels.
  • While NO production and vWf/factor VIIIc levels increased with exercise, they were similar between conditions.
  • Significant alterations in V(E)/V(CO2) and P(ETCO2) were observed during exercise after methionine loading, indicating changes in ventilation/perfusion (V/Q) matching.

Conclusions:

  • Acute hyperhomocysteinaemia induces subtle but significant changes in respiratory gas exchange.
  • These changes suggest pulmonary vascular endothelial dysfunction and a V/Q mismatch.
  • Non-invasive tests can detect these effects in the pulmonary circulation.