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Computational prediction of transcription-factor binding site locations
1Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. mlbulyk@rascal.med.harvard.edu
Genome Biology
|January 8, 2004
Abstract:
Identifying genomic locations of transcription-factor binding sites, particularly in higher eukaryotic genomes, has been an enormous challenge. Various experimental and computational approaches have been used to detect these sites; methods involving computational comparisons of related genomes have been particularly successful.