Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Working memory for complex scenes: age differences in frontal and hippocampal activations.

Denise C Park1, Robert C Welsh, Christy Marshuetz

  • 1The Beckman Institute, University of Illinois at Urbana-Champaign 61801, USA. denisep@uiuc.edu

Journal of Cognitive Neuroscience
|January 8, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A vendor-neutral functional MRI acquisition protocol for multi-site studies.

Aperture neuro·2026
Same author

Spatiotemporal Maps for Dynamic MRI Reconstruction.

IEEE transactions on computational imaging·2026
Same author

Velocity Spectrum Imaging Using Velocity Encoding Preparation Pulses.

Magnetic resonance in medicine·2025
Same author

The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI): Overview of consortium sites and anticipated enrollment.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

A vendor-neutral functional MRI acquisition protocol for multi-site studies.

medRxiv : the preprint server for health sciences·2025
Same author

Revisiting Centiloids using AI.

Research square·2025

Older adults show different brain activity patterns in working memory tasks compared to younger adults, particularly in frontal and hippocampal regions, despite similar task performance.

Area of Science:

  • Cognitive Neuroscience
  • Neuroimaging
  • Aging Research

Background:

  • Working memory function undergoes changes with age.
  • Previous research suggests age-related differences in brain activation patterns during cognitive tasks.
  • Understanding these differences is crucial for comprehending cognitive aging.

Purpose of the Study:

  • To investigate age-related differences in brain activation within frontal and hippocampal regions during a working memory task.
  • To compare neural engagement between younger and older adults under varying working memory conditions.

Main Methods:

  • Event-related functional magnetic resonance imaging (fMRI) was employed.
  • Participants included younger and older adults performing a working memory task involving maintenance and probe intervals.

Related Experiment Videos

  • Task conditions included viewing (extended visual) and maintaining photographs of real-world scenes.

    • Main Results:

    • Behavioral accuracy was comparable between age groups and conditions.
    • Younger adults exhibited increased left anterior hippocampal activation in the extended visual condition compared to the maintenance condition.
    • Older adults demonstrated greater left and right inferior frontal activation during the probe interval compared to younger adults.

    Conclusions:

    • Despite equivalent behavioral performance, older adults show distinct neural engagement patterns in working memory.
    • Increased frontal activation in older adults may represent a compensatory mechanism for reduced hippocampal activity.
    • These findings highlight qualitatively different engagement of frontal and hippocampal structures in older adults during working memory.