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Prothrombotic factors in children with otitis media and sinus thrombosis

Yael Oestreicher-Kedem1, Eyal Raveh, Liora Kornreich

  • 1Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Beilinson Campus, Israel. dkyo@barak-online.net.il

The Laryngoscope
|January 8, 2004
PubMed

Insights

Children with acute otitis media (AOM) complicated by venous sinus thrombosis (VST) may have a prothrombotic tendency. This suggests a potential link between clotting disorders and VST in pediatric patients.

Area of Science:

  • Pediatric Otolaryngology
  • Neurology
  • Hematology

Background:

  • Venous sinus thrombosis (VST) is a significant intracranial complication of acute otitis media (AOM).
  • Prothrombotic disorders, both inherited and acquired, are suspected risk factors for VST.
  • Understanding these risk factors is crucial for effective prevention and treatment.

Purpose of the Study:

  • To investigate the presence of a prothrombotic tendency in children diagnosed with AOM complicated by VST.
  • To explore potential therapeutic and preventive strategies based on identified risk factors.
  • To add to the body of evidence regarding VST etiology in pediatric populations.

Main Methods:

  • Retrospective review of patient records from a tertiary referral center (1999-2002).
  • Inclusion criteria: children hospitalized for AOM with acute mastoiditis and VST.
  • Laboratory evaluation for hypercoagulability was performed on all included children.

Main Results:

  • Five out of seven pediatric patients exhibited prothrombotic disorders.
  • Identified disorders included elevated lipoprotein apolipoprotein (Lp[a]), antiphospholipid syndrome markers, and Factor V Leiden mutation.
  • Patients presented with varying numbers of prothrombotic abnormalities, ranging from one to three.

Conclusions:

  • A prothrombotic tendency appears to be present in children experiencing AOM complicated by mastoiditis and VST.
  • Further research is warranted to fully elucidate the extent and implications of this tendency.
  • Findings suggest a potential role for thrombophilia screening in this patient group.
Abstract

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