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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
Published on: April 7, 2021
Clinical profile of ARDS
A Vigg1, S Mantri, Avanti Vigg
1Department of Respiratory Medicine, Apollo Hospitals, Hyderabad.
The Journal of the Association of Physicians of India
|January 9, 2004
Summary
This study identified the clinical patterns of Indian patients who died from Acute Respiratory Distress Syndrome (ARDS). Primary pulmonary infection and severe sepsis were significant risk factors associated with ARDS mortality.
Area of Science:
- Critical Care Medicine
- Pulmonology
- Infectious Diseases
Background:
- Limited data exists on Acute Respiratory Distress Syndrome (ARDS) patterns in the Indian population.
- Anecdotal reports suggest associations between tropical diseases and ARDS, but these are not well-described in Indian literature.
Purpose of the Study:
- To identify the clinical patterns of Indian patients who died from ARDS.
- To understand the demographic and etiological factors contributing to ARDS mortality in India.
Main Methods:
- Retrospective study of 98 patients who died of ARDS between January 1999 and June 2002.
- Diagnosis of ARDS based on American/European consensus criteria.
- Data collected included demographics, associated illnesses, ICU stay, mechanical ventilation, sepsis, and organ failure.
Main Results:
- Primary pulmonary infection was the most common association (30% of patients).
- Severe sepsis with multi-organ failure was observed in 18% of patients.
- Pseudomonas and Klebsiella were the most frequently isolated organisms from body fluids.
Conclusions:
- Primary pulmonary infection is a significant contributor to ARDS in Indian patients.
- Severe sepsis is a major risk factor for ARDS and mortality.
- Further research is needed to elucidate the role of tropical diseases in ARDS pathogenesis in India.
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