Clinical pharmacodynamics of antifungals

David Andes1

  • 1Department of Medicine, Section of Infectious Diseases, University of Wisconsin, 600 Highland Avenue, Room H4/572, Madison, WI 53792, USA. dra@medicine.wisc.ed

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
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Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

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Pharmacokinetics: Drug–Drug Interactions

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Pharmacodynamics: Overview and Principles01:21

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