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Updated: Aug 29, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Fundamental principles of evidence-based medicine applied to mental health care
Robert E Drake1, Stanley D Rosenberg, Gregory B Teague
1Department of Psychiatry, Dartmouth Medical School, Psychiatric Research Center, 2 Whipple Place, Lebanon, NH 03766, USA. robert.e.drake@dartmouth.edu
Abstract:
This article discusses the fundamental principles of evidence-based medicine: using the best available evidence, individualizing the evidence, attending to patient preferences, and expanding clinical expertise. These principles have important implications for the adoption of evidence-based practices in mental health care.
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