Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High-throughput screening in academia: the Harvard experience.

Ross L Stein1

  • 1Laboratory for Drug Discovery in Neurodegeneration, Department of Neurology, Harvard Medical School, Cambridge, MA 02139, USA. rstein@rics.bwh.harvard.edu

Journal of Biomolecular Screening
|January 9, 2004
PubMed
Summary

Academic scientists are adopting high-throughput screening (HTS) for drug discovery and chemical genetics. This approach enables testing novel hypotheses and discovering new biologic modulators.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kinetic and Mechanistic Studies of Human Oligoadenylate Synthetase 1.

Biochemistry·2024
Same author

Targeting the Synthetic Lethal Relationship between FOCAD and TUT7 Represents a Potential Therapeutic Opportunity for TUT4/7 Small-Molecule Inhibitors in Cancer.

Molecular cancer therapeutics·2024
Same author

Kinetic and Mechanistic Studies of the Terminal Uridylyltransferase, Zcchc11 (TUT4).

Biochemistry·2022
Same author

Mechanisms of macromolecular reactions.

History and philosophy of the life sciences·2022
Same author

Kinetic Studies of the Activation of <i>Bordetella pertussis</i> Adenylate Cyclase by Calmodulin.

Biochemistry·2022
Same author

Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.

Toxicon : official journal of the International Society on Toxinology·2017

Area of Science:

  • Biotechnology
  • Academic Science

Background:

  • High-throughput screening (HTS) traditionally used in industry is now being adopted by academic scientists.
  • University HTS laboratories are established for drug discovery, chemical genetics, or training.

Purpose of the Study:

  • To examine the role of drug discovery, chemical genetics, and training in academic HTS laboratories.
  • To review the histories and operations of four HTS laboratories at Harvard Medical School.

Main Methods:

  • Case study analysis of four HTS laboratories at Harvard Medical School and affiliated institutions.
  • Definition and examination of the impact of drug discovery, chemical genetics, and training on academic science.

Main Results:

  • HTS adoption in academia is driven by goals of drug discovery, chemical genetics, and training.

Related Experiment Videos

  • Analysis of four Harvard laboratories reveals the initial motivations and ongoing roles of these activities.
  • HTS provides tools to test previously untestable hypotheses, enabling novel discoveries.

    • Conclusions:

    • Academic HTS laboratories are crucial for advancing drug discovery and chemical genetics.
    • The integration of HTS in academia facilitates the testing of novel hypotheses and discovery of new biologic modulators.
    • Successful establishment of academic HTS requires careful attention to operational and strategic concerns.