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Novel therapeutic molecular targets for prostate cancer: the mTOR signaling pathway and epidermal growth factor

Anthony W Tolcher1

  • 1Director Clinical Research, Institute for Drug Development Cancer Therapy and Research Center, San Antonio, Texas, USA.

The Journal of Urology
|January 10, 2004
PubMed
Abstract

Insights

Novel molecular targets show promise for prostate cancer chemoprevention. Research supports their use in preventing cancer by targeting key cellular pathways like PI3/Akt and EGFR.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Molecularly targeted therapies are emerging for advanced cancers.
  • This presents an opportunity for cancer chemoprevention strategies.

Purpose of the Study:

  • To review the scientific rationale and evidence for novel molecular targets in cancer chemoprevention.
  • To focus specifically on prostate cancer chemoprevention.

Main Methods:

  • A literature search was conducted using PubMed/MEDLINE.
  • Included basic science and clinical trial data.

Main Results:

  • Two key targets, the PI3/Akt pathway and epidermal growth factor receptor (EGFR), are central to cell proliferation and malignant transformation.
  • Novel therapies targeting these pathways are in late-stage clinical trials (Phase II and III).

Conclusions:

  • Current research supports the consideration of these novel molecular targets for future prostate cancer chemoprevention.
  • Targeted therapies offer a promising avenue for preventing prostate cancer development.

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