Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

APS and the brain.

J Sastre-Garriga1, X Montalban

  • 1Unitat de Neuroimmunology Clínica, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Lupus
|January 13, 2004
PubMed
Summary
This summary is machine-generated.

Antiphospholipid antibody syndrome (APS) frequently causes neurological issues, including cerebrovascular disease and cognitive impairment. While some neurological symptoms are clearly linked to antiphospholipid antibodies (APLab), others require further research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis.

NeuroImage. Clinical·2025
Same author

Synthetic MRI in Progressive MS: Associations with Disability.

AJNR. American journal of neuroradiology·2025
Same author

[XVI Post-ECTRIMS Meeting: review of the new developments presented at the 2023 ECTRIMS Congress (II)].

Revista de neurologia·2024
Same author

[XVI Post-ECTRIMS Meeting: review of the new developments presented at the 2023 ECTRIMS Congress (I)].

Revista de neurologia·2024
Same author

[15th Post-ECTRIMS Meeting: a review of the latest developments presented at the 2022 ECTRIMS Congress (Part II)].

Revista de neurologia·2023
Same author

[Revista de Neurologia is celebrating its 50th anniversary].

Revista de neurologia·2023
Same journal

Association of systemic lupus erythematosus with 90-day readmission following heart failure hospitalization: A national readmission database (NRD) analysis, 2016-2017.

Lupus·2026
Same journal

Association of GPX4 rs713041 and rs4807542 polymorphisms and serum GPX4 levels in Chinese patients with systemic lupus erythematosus.

Lupus·2026
Same journal

Giant cell myocarditis in an 18-year-old patient with new-onset systemic lupus erythematosus: A fatal case of rapidly progressing heart failure.

Lupus·2026
Same journal

An evidence-based specialist nursing protocol for children with hypoprothrombinemia-lupus anticoagulant syndrome (HLAS) and its application research.

Lupus·2026
Same journal

T-bet expression in B cell subsets: Association with T peripheral helper cells and clinical activity in systemic lupus erythematosus.

Lupus·2026
Same journal

Autonomic dysfunction in systemic lupus erythematosus and systemic sclerosis.

Lupus·2026
See all related articles

Area of Science:

  • Neurology
  • Immunology
  • Rheumatology

Background:

  • Antiphospholipid antibody syndrome (APS) is an autoimmune disorder associated with an increased risk of blood clots and pregnancy complications.
  • Neurological manifestations are common in APS, significantly impacting patient morbidity and quality of life.

Purpose of the Study:

  • To review the spectrum of neurological syndromes associated with APS.
  • To elucidate the potential pathogenetic mechanisms linking antiphospholipid antibodies (APLab) to these neurological events.

Main Methods:

  • Literature review of studies investigating neurological manifestations in APS.
  • Analysis of proposed mechanisms, including cerebrovascular disease, immunological pathways, and cardioembolism.

Main Results:

Related Experiment Videos

  • Cerebrovascular disease is a leading neurological symptom in APS, often due to accelerated atherogenesis and cardioembolism.
  • Chorea and epileptic seizures are linked to APS through both vascular and immunological mechanisms.
  • Cognitive impairment, including multi-infarct dementia and less severe forms, is associated with APS.
  • A definitive causal link between APLab and common headaches is uncertain; associations with transverse myelopathy and multiple sclerosis-like presentations require further investigation.

Conclusions:

  • Neurological syndromes are a significant component of APS, with cerebrovascular disease being the most prevalent.
  • Understanding the diverse pathogenetic mechanisms is crucial for managing APS-related neurological complications.
  • Further research is needed to clarify the role of APLab in certain neurological presentations like transverse myelopathy and demyelinating syndromes.