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Osteoclast numbers in Lewis rats with adjuvant-induced arthritis: identification of preferred sites and parameters
1Department of Pathology, Amgen, Inc., Thousand Oaks, CA, USA. bradgempath@aol.com
Veterinary Pathology
|January 13, 2004
Abstract:
This study defined the best site for quantifying osteoclasts in male Lewis rats with mycobacteria-induced adjuvant arthritis. Hind paw sections of normal and arthritic rats (n = 6 per group) taken 7 days after disease onset were stained for osteoclasts using an anti-human cathepsin K primary antibody. Erosions and osteoclasts were assessed using semiquantitative scores (entire section) and quantitative measures (in calcaneus, navicular tarsal, and tibia). Bone area in arthritic rats was significantly reduced (P
