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Antigenotoxic effects of water extract from Korean fermented soybean paste (doen-jang)

Jong-Gyu Kim1

  • 1Department of Public Health, Keimyung University, 1000 Sindang-Dong, Dalseo-Gu, Daegu 704-701, Korea. jgkim@kmu.ac.kr

Journal of Food Protection
|January 14, 2004
PubMed

Insights

Korean soybean paste extract showed significant antimutagenic and antigenotoxic effects against aflatoxin B1. This natural compound suppressed mutagenicity in bacterial assays and chromosome damage in cell tests.

Area of Science:

  • Food Science
  • Toxicology
  • Genetics

Background:

  • Aflatoxin B1, a potent carcinogen produced by Aspergillus molds, poses a significant health risk.
  • Soybean paste (doen-jang) is a traditional fermented food with potential health benefits.
  • Investigating natural compounds for antigenotoxic properties is crucial for public health.

Purpose of the Study:

  • To evaluate the genotoxicity of Korean soybean paste water extract.
  • To assess the antigenotoxic activity of the extract against aflatoxin B1-induced damage.
  • To explore the potential of doen-jang as a protective agent against toxic insults.

Main Methods:

  • Bacterial reverse mutation assay (Ames test) using Salmonella Typhimurium strains.
  • In vitro chromosome aberration test using Chinese hamster lung (CHL) cells.
  • Assessment of cytotoxicity, mutagenicity, and antigenotoxic effects of the water extract.

Main Results:

  • The water extract of Korean soybean paste exhibited no inherent cytotoxicity or mutagenicity.
  • The extract significantly reduced mutagenic revertants in Salmonella Typhimurium TA100 (P < 0.05).
  • Significant inhibition of chromosome aberrations was observed in CHL cells (P < 0.05), with a dose-response relationship.

Conclusions:

  • Water extract from Korean soybean paste demonstrates significant antigenotoxic and antimutagenic properties.
  • The extract effectively protects against aflatoxin B1-induced genotoxicity.
  • Korean soybean paste holds potential as a natural source of antigenotoxic compounds.

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