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Hodgkin's lymphoma presenting as extradural spinal cord compression
T Roshni Paul1, C Sundaram, A K Reddy
1Department of Pathology and Neurosurgery, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad 500082.
The Journal of the Association of Physicians of India
|January 15, 2004
Summary
Spinal cord compression from Hodgkin's lymphoma is rare, predominantly affecting males. Histological review and clinical correlation are crucial for accurate diagnosis and differentiating it from other conditions.
Area of Science:
- Oncology
- Neurology
- Pathology
Background:
- Hodgkin's lymphoma rarely presents with spinal cord compression, estimated in only 5% of cases.
- This presentation necessitates careful diagnostic consideration due to its rarity.
Purpose of the Study:
- To review the histology of Hodgkin's lymphoma cases causing spinal cord compression.
- To correlate histological findings with clinical data, including lymphadenopathy, hepatosplenomegaly, and marrow involvement.
Main Methods:
- Retrospective study of histopathology records from 1987-2002.
- Review of clinical profiles and histology, supplemented by immunohistochemistry when needed.
Main Results:
- Twelve cases were identified, with a male predominance (11 males, 1 female).
- Patient age ranged from 8 to 62 years (median 32 years).
- Spinal cord involvement occurred at thoracic (8), lumbar (2), and cervical (2) levels.
Conclusions:
- Accurate histological diagnosis of Hodgkin's lymphoma with spinal cord compression requires clinical awareness.
- Differential diagnoses include inflammation, non-Hodgkin's lymphoma, tuberculosis, and eosinophilic granuloma.
- Comprehensive clinical evaluation is vital for interpreting histopathology.