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Trophoblastic hyperthyroidism.

L D Padmanabhan¹, R Mhaskar, A Mhaskar

¹Department of Obstetric and Gynaecology, St. John's Medical College Hospital, Bangalore 560 034, Karnataka, India.

The Journal of the Association of Physicians of India

|January 15, 2004

Summary

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Hyperthyroidism can be caused by gestational trophoblastic disease. This study analyzed four women with this condition, finding high beta-hCG levels and hypermetabolic symptoms requiring treatment.

Area of Science:

Endocrinology
Obstetrics & Gynecology
Oncology

Background:

Gestational trophoblastic disease (GTD) is a rare pregnancy complication.
Hyperthyroidism can be a rare manifestation of GTD.

Observation:

This study analyzed four women with hyperthyroidism secondary to GTD.
Clinical presentations included vomiting, vaginal bleeding, tachycardia, and thyromegaly.
All patients had significantly elevated beta-human chorionic gonadotropin (beta-hCG) levels (>500,000 mlu/ml).

Findings:

Two cases involved molar pregnancy, one a partial mole, and one persistent GTD.
Three women required treatment for hyperthyroid symptoms.
One woman presented with biochemical hyperthyroidism only.

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Implications:

Elevated beta-hCG in GTD can trigger hyperthyroidism.
Prompt diagnosis and management of GTD-associated hyperthyroidism are crucial.
Understanding this association aids in comprehensive patient care for GTD.