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Published on: May 6, 2021
EUS-guided photodynamic therapy of the pancreas: a pilot study
Hoi-Hung Chan1, Norman Shizuaki Nishioka, Mari Mino
1Gastrointestinal Unit, Gastrointestinal Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Background:
Photodynamic therapy of pancreatic cancer by using percutaneously placed light catheters has been reported. The feasibility and safety of EUS-guided photodynamic therapy of the pancreas was studied in a porcine model.
Methods:
After injection of porfimer sodium, a 19-gauge needle was inserted into the pancreas, the liver, the spleen, and the kidney under EUS guidance. A small diameter quartz optical fiber was passed through the EUS needle and used to illuminate the tissue with laser light. The tissue response to photodynamic therapy was examined.
Results:
Localized tissue necrosis was achieved in all organs, without significant complication. There was no significant difference in inflammation induced by photodynamic therapy within the various organs.
Conclusions:
EUS-guided photodynamic therapy is a safe and simple technique that can induce small areas of focal tissue ablation within the liver, the pancreas, the kidney, and the spleen, and potentially could be used to treat a variety of benign and malignant conditions.
