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Updated: Aug 9, 2026

Biomimetic Materials to Characterize Bacteria-host Interactions
Published on: November 16, 2015
Biological activity of bacterial lectins and their molecular complexes with heterocyclic bis-adducts
H V Welchinskaya1, B Piecuszak, E A Kovalenko
1National Medical University, 13 Shevchenko Blvd, Kyiv, 01004, Ukraine.
Abstract:
A new convenient method for the preparation of heterocyclic bis-adducts: of imidazole, benzimidazole, uracile with 1,1,1-trifluoro-2-bromo-2-chloroethane is described. The reactions are catalysed by the 18-crown-6-complex. The critical toxicity and antitumour activity of saprophytic strains Bacillus genus (B. subtilis 668 IMV and B. polymyxa 102 KSU) extracellular lectins were studies. It was discovered that these substances apply to a few toxic preparations and have a expression antitumour action on the tumours: Walker carcinosarcoma 256, Pliss' lymphosarcoma and Sarcoma 45. The new molecular complexes were created with bacterial lectins and the same heterocyclic-bis-adducts of unsubstituted benzimidazole and 6-methyluracile. A strongly antitumour effect of these complexes has been discovered: of growth relaxation of Pliss' lymphosarcoma tumour mass was 62.5-82.01%.
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