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Clostridium perfringens pleuropulmonary infection and septic shock: case report and population-based laboratory

Shannon Jackson1, Daniel B Gregson, Sean McFadden

  • 1Department of Medicine, Calgary Laboratory Services, University of Calgary, and the Calgary Health Region, Calgary, Alberta, Canada.

Scandinavian Journal of Infectious Diseases
|January 16, 2004
PubMed

Insights

Clostridium perfringens can cause severe lung infections like necrotizing pneumonia and empyema. Invasive disease incidence is low but risk increases with age.

Area of Science:

  • Medicine
  • Infectious Diseases
  • Pulmonology

Background:

  • Clostridium perfringens is a bacterium known to cause gas gangrene and food poisoning.
  • Invasive infections, particularly pneumonia and empyema, are rare but can be life-threatening.

Observation:

  • A rare case of necrotizing pneumonia, empyema, and septic shock caused by Clostridium perfringens is presented.
  • Population-based laboratory surveillance was conducted.

Findings:

  • The annual incidence of invasive Clostridium perfringens disease was found to be 0.83 per 100,000 population.
  • A significant age-related increase in the risk of acquiring invasive C. perfringens disease was observed.

Implications:

  • Highlights the potential severity of Clostridium perfringens infections.
  • Suggests increased surveillance and awareness in elderly populations.
  • Informs clinical management of severe bacterial pneumonia and sepsis.

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