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Early atherogenesis in senescence-accelerated mice
Mark Fenton1, Hsiu-Lin Huang, Ying Hong
1The Cell Biology Group at the Centre for Cardiovascular Biology and Medicine, Department of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JJ, UK.
Experimental Gerontology
|January 16, 2004
Summary
Accelerated aging mice (SAM-P/8) showed increased susceptibility to atherosclerosis, developing more prevalent and extensive fatty lesions compared to normal aging mice (SAM-R/1). This suggests aging rate influences early atherogenesis.
Area of Science:
- Cardiovascular Biology
- Aging Research
- Animal Models
Background:
- Atherosclerosis is a complex disease influenced by aging.
- Senescence-accelerated mouse models offer insights into age-related pathologies.
- Understanding susceptibility in aging is crucial for disease prevention.
Purpose of the Study:
- To investigate if accelerated aging mice (SAM-P/8) are more prone to atherosclerosis than normal aging mice (SAM-R/1).
- To compare atheromatous lesion formation and macrophage infiltration between the two mouse strains on a Western-type diet.
Main Methods:
- Senescence-accelerated prone (SAM-P/8) and resistant (SAM-R/1) mice were fed a Western-type diet for 17 weeks.
- Serum lipid profiles were analyzed before and after the diet.
- Aortic root cryosections were stained for lipid deposition (Oil red O) and macrophage infiltration (immunohistochemistry).
Main Results:
- Despite similar lipid profile changes, SAM-P/8 mice exhibited significantly more prevalent and extensive fatty lesions in the aortic root.
- Lipid lesions in SAM-P/8 mice showed a higher frequency of macrophage invasion compared to SAM-R/1 mice.
- Accelerated aging is associated with increased susceptibility to early atherogenesis.
Conclusions:
- Mice with accelerated aging are more susceptible to developing atherosclerosis.
- This heightened susceptibility may be linked to oxidative stress and cellular replicative capacity abnormalities.
- Accelerated aging models are valuable for studying early atherogenesis and age-related cardiovascular risks.