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[Amyloidosis complicating psoriatic arthritis]
M Bergis1, H Dega, V Planquois
1Service de Dermatologie I, Hôpital Saint-Louis, Paris.
Annales De Dermatologie Et De Venereologie
|January 16, 2004
Summary
Psoriasis can lead to secondary AA amyloidosis, a rare complication. Early detection and treatment, including colchicine, may help stabilize proteinuria in affected patients.
Area of Science:
- Rheumatology
- Nephrology
- Dermatology
Background:
- Secondary AA amyloidosis is a known complication of chronic inflammatory conditions.
- Psoriasis is an uncommon cause of secondary AA amyloidosis, with limited documented cases.
Observation:
- A 62-year-old male with a six-year history of psoriasis and recent-onset arthritis presented with proteinuria.
- This proteinuria indicated the presence of renal and hepatic AA amyloidosis.
Findings:
- Treatment with methotrexate, enalapril, and colchicine stabilized proteinuria for two years.
- Amyloidosis in psoriatic patients often complicates long-standing arthritic conditions.
- This case highlights the rapid onset of amyloidosis following initial articular symptoms in psoriasis.
Implications:
- Secondary AA amyloidosis presents with renal or gastrointestinal symptoms and generally has a poor prognosis.
- Effective treatment for secondary AA amyloidosis is challenging, often requiring systemic therapies.
- Colchicine may offer a beneficial therapeutic option for managing this condition.