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Published on: January 17, 2018
Sinonasal neuroendocrine carcinoma in association with SIADH
Nilesh R Vasan1, Jesus E Medina, Vikki A Canfield
1Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, P.O. Box 26901, WP 1360, Oklahoma City, Oklahoma 73190, USA.
Background:
Neuroendocrine carcinoma (NEC) is a rare malignancy of the nasal cavity or paranasal sinuses. The syndrome of inappropriate ADH secretion (SIADH) has not been previously reported in association with this cancer.
Methods:
We report a 30-year-old woman with histologically confirmed neuroendocrine carcinoma who also demonstrated SIADH. After successful chemotherapy and radiotherapy treatment for the neoplasm, her SIADH resolved. A literature search found eight cases of olfactory neuroblastoma (ONB) associated with SIADH, four of which resolved after treatment of the malignancy.
Results:
Treatment of the underlying malignancy resulted in the immediate resolution of the SIADH.
Conclusions:
We report the first case of SIADH associated with NEC, which resolved after treatment of the cancer. A direct cause and effect between ONB/nasal NEC and SIADH has been established in previous reports.
