[Possibilities of monitoring oxidative damage and its clinical aspects]

In their earlier work the authors reviewed some methods, which appeared to be suitable for monitoring the redox-status of the human organism and, therefore, may be applied under routine clinical laboratory circumstances. This possibility can lead to a new perspective to set up epidemiological studies in different populations in order to investigate connecting points between the manner of life, alimentary customs (especially consumption of antioxidants), and the risk of chronic or acute illnesses. In this review the authors surveyed different methods for the measurements of end products (lipids, proteins, nucleic acids) produced by cells and tissues through oxidative injury, caused by the free radicals. These methods have already served the work of scientists for many years, helping them to obtain experience about the pathomechanisms of different diseases. With the help of these measurements it could be possible to monitor the results of medical therapy or surgical treatments, or in the field of chronic illnesses e.g. diabetes, to predict the possible development of late complications.