Induced fit, drug design, and dUTPase

Critical Role of Water Molecules in Proton Translocation by the Membrane-Bound Transhydrogenase.

Structure (London, England : 1993)·2017

Halogen-π Interactions in the Cytochrome P450 Active Site: Structural Insights into Human CYP2B6 Substrate Selectivity.

ACS chemical biology·2017

Role of the Conserved Valine 236 in Access of Ligands to the Active Site of Thermus thermophilus ba3 Cytochrome Oxidase.

Biochemistry·2016

Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry.

Biophysical chemistry·2016

Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.

Biochemistry·2016

Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism.

Molecular pharmacology·2016

Conformational signatures of native ligand and pharmacochaperone binding in rhodopsin.

Structure (London, England : 1993)·2026

Ligand-dependent interdomain rearrangements drive catalysis by acetyl-CoA synthetases.

Structure (London, England : 1993)·2026

Meet the author: Blake Wiedenheft.

Structure (London, England : 1993)·2026

How a stabilizing modification leads to misfolding disease.

Structure (London, England : 1993)·2026

How frog proteins soak up toxins.

Structure (London, England : 1993)·2026

Fragment screening in focus.

Structure (London, England : 1993)·2026

Suitability of Oral Formulations Available to Children at the Time of Pediatric Labeling.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2026

Association between integrated specialty pharmacy care model and pharmaceutical access and costs.

Health affairs scholar·2026

Polyphyllins ameliorate imiquimod-induced psoriatic skin barrier disruption and lesions in mice by inhibiting inflammatory infiltration with accelerated recovery effects.

Frontiers in immunology·2026

Drug self-administration in head-fixed mice.

Nature protocols·2026

Tirzepatide Persistence and Associated Changes in Clinical Outcomes in US Adults With Obesity or Overweight: A 6-Month Claims Database Analysis.

Diabetes, obesity & metabolism·2026

ChemScan: A computational platform for drug selection in platelet-mediated delivery.

Computational biology and chemistry·2026

Related Experiment Videos

Induced fit, drug design, and dUTPase

Related Concept Videos

Critical Role of Water Molecules in Proton Translocation by the Membrane-Bound Transhydrogenase.

Halogen-π Interactions in the Cytochrome P450 Active Site: Structural Insights into Human CYP2B6 Substrate Selectivity.

Role of the Conserved Valine 236 in Access of Ligands to the Active Site of Thermus thermophilus ba3 Cytochrome Oxidase.

Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry.

Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.

Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism.

Conformational signatures of native ligand and pharmacochaperone binding in rhodopsin.

Ligand-dependent interdomain rearrangements drive catalysis by acetyl-CoA synthetases.

Meet the author: Blake Wiedenheft.

How a stabilizing modification leads to misfolding disease.

How frog proteins soak up toxins.

Fragment screening in focus.

Suitability of Oral Formulations Available to Children at the Time of Pediatric Labeling.

Association between integrated specialty pharmacy care model and pharmaceutical access and costs.

Polyphyllins ameliorate imiquimod-induced psoriatic skin barrier disruption and lesions in mice by inhibiting inflammatory infiltration with accelerated recovery effects.

Drug self-administration in head-fixed mice.

Tirzepatide Persistence and Associated Changes in Clinical Outcomes in US Adults With Obesity or Overweight: A 6-Month Claims Database Analysis.

ChemScan: A computational platform for drug selection in platelet-mediated delivery.

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Induced fit, drug design, and dUTPase

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