Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quantitative NumART2* mapping in functional MRI studies at 1.5 T.

Gisela E Hagberg1, Marta Bianciardi, Fabiana Patria

  • 1Laboratory of Functional Neuroimaging, Fondazione Santa Lucia IRCCS, Rome, Italy. g.hagberg@hsantalucia.it

Magnetic Resonance Imaging
|January 17, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CSF turnover dysfunction: a hidden early biomarker in iRBD?

NPJ Parkinson's disease·2026
Same author

Down-sloping high-frequency audiometric findings in ENT-MS-12 auditory screen-positive patients with relapsing-remitting multiple sclerosis: A pilot case series.

Multiple sclerosis and related disorders·2026
Same author

Task demands and visual context naturalness modulate gravitational expectation during ocular tracking of temporarily occluded ballistic trajectories.

PloS one·2026
Same author

Effectiveness of vestibular physical therapy on balance and dizziness in people with multiple sclerosis: A systematic review and meta-analysis.

Journal of vestibular research : equilibrium & orientation·2026
Same author

Structure-function coupling in the human brainstem.

bioRxiv : the preprint server for biology·2026
Same author

PTSD and Audio Vestibular Symptoms: A Two-Way Street Driven by the Amygdala? A Speculative Hypothesis.

Brain sciences·2026

Quantitative mapping using NumART2* in functional MRI (fMRI) offers improved spatial specificity for detecting brain activation compared to conventional EPI. This advanced technique enhances statistical detection while reducing false positives, leading to more precise fMRI results.

Area of Science:

  • Neuroimaging
  • Functional Magnetic Resonance Imaging (fMRI)
  • Quantitative MRI

Background:

  • Conventional single-echo echo planar imaging (EPI) in fMRI is susceptible to echo time-dependent signal variations.
  • Accurate quantitative mapping of T2* and proton density is crucial for reliable fMRI analysis.

Purpose of the Study:

  • To evaluate the performance of NumART2* (Numerical Algorithm for Real time T2*) for quantitative mapping in motor activation fMRI.
  • To compare NumART2* with conventional single-echo EPI for T2* and proton density mapping.

Main Methods:

  • Multi-echo EPI and NumART2* were employed for quantitative T2* and proton density mapping.
  • Simulations were conducted to analyze echo time-dependent signal variations.
  • Five healthy participants were scanned twice, comparing NumART2* against single-echo EPI (TE=64 ms).

Related Experiment Videos

Main Results:

  • NumART2* demonstrated unaffected relative T2* changes, unlike single-echo EPI where contrast varied with baseline T2*.
  • fMRI activation patterns from NumART2* showed improved statistical detection but fewer activated voxels, indicating superior spatial specificity.
  • A statistically significant increase in proton density was observed in areas detected by conventional EPI but missed by NumART2*, suggesting potential confounding effects.

Conclusions:

  • NumART2* offers enhanced spatial specificity in fMRI by providing more precise T2* mapping.
  • The technique may reduce false positives by mitigating effects like inflow and dephasing.
  • Further investigation into proton density changes is warranted to fully understand fMRI signal variations.