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  3. Structure-function Coupling In The Human Brainstem.
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  3. Structure-function Coupling In The Human Brainstem.

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Structure-function coupling in the human brainstem.

Asa Farahani1, Subhranil Koley2,3, Justine Y Hansen4

  • 1Montréal Neurological Institute, McGill University, Montréal, QC, Canada.

Biorxiv : the Preprint Server for Biology
|April 17, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

This study maps brainstem nuclei connections to the cortex using high-resolution MRI, revealing their role in sensory, motor, and cognitive functions. Brainstem structure-function coupling influences overall brain organization.

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Connectomics

Background:

  • Brainstem nuclei are crucial for modulating central nervous system activity.
  • Brainstem nuclei are typically excluded from brain connectome reconstructions due to imaging challenges.
  • The impact of brainstem nuclei on brain structure-function coupling remains largely unknown.

Purpose of the Study:

  • To reconstruct structural and functional brain connectomes that include brainstem nuclei.
  • To investigate the relationship between brainstem nuclei and cortical structures.
  • To understand how brainstem nuclei influence structure-function coupling across the brain.

Main Methods:

  • Utilized high-resolution 7 Tesla magnetic resonance imaging (MRI).
  • Reconstructed structural and functional connectomes encompassing the cortex and 58 brainstem nuclei (midbrain, pons, medulla).
  • Analyzed structural connectional profiles and their correlation with functional connectivity.

    • Main Results:

    • Identified structural connectional profiles of brainstem nuclei to the cortex, aligning with sensory, motor, and cognitive functions.
    • Demonstrated a positive correlation between structural and functional connectivity in brainstem-augmented connectomes.
    • Found heterogeneous structure-function coupling across brainstem nuclei, with highest coupling in modulatory and relay nuclei.

    Conclusions:

    • This work provides an initial framework for understanding the brainstem's influence on brain-wide structure-function relationships.
    • The findings highlight the importance of including brainstem nuclei in connectomic studies.
    • Brainstem nuclei play a significant role in shaping cognitive and sensory-motor functions through their connectivity patterns.