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Related Experiment Videos

Poly(dimethylsiloxane) coatings for controlled drug release--polymer modifications.

J Schulze Nahrup1, Z M Gao, J E Mark

  • 1Industrial Pharmacy Graduate Program, University of Cincinnati Medical Center, 3223 Eden Avenue, Cincinnati, OH 45267-0004, USA.

International Journal of Pharmaceutics
|January 17, 2004
PubMed
Summary

Modified poly(dimethylsiloxane) (PDMS) coatings with polyethylene glycol (PEG) enabled zero-order drug release from tablets. Higher PEG concentrations achieved sustained release over 24 hours.

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Area of Science:

  • Materials Science
  • Pharmaceutical Technology
  • Polymer Chemistry

Background:

  • End-hydroxylated poly(dimethylsiloxane) (PDMS) formulations require modification for controlled drug delivery applications.
  • Spray-coating processes necessitate specific material properties for effective tablet coating.

Purpose of the Study:

  • To investigate modified PDMS formulations for spray-coating tablet cores.
  • To achieve zero-order drug release kinetics using these modified coatings.
  • To evaluate the impact of crosslinker and channeling agent variations on coating properties and drug release.

Main Methods:

  • Modified PDMS formulations using different crosslinkers (TEOS, SIG) and channeling agents (lactose, MCC, PEG).
  • Characterization of dispersion properties (particle size, viscosity) and mechanical properties of free films.

Related Experiment Videos

  • In vitro release studies of hydrochlorothiazide from coated tablets in a conventional coating pan.

    • Main Results:

    • All PDMS dispersions were suitable for spray-coating.
    • Copolymer addition negatively impacted mechanical properties, precluding its use in free films.
    • Formulations with polyethylene glycol (PEG) were most effective for controlling drug release, even at low coating weights (5%).
    • Constant release rates were achieved with up to 25% PEG, with 50% PEG yielding 63% drug release over 24 hours.

    Conclusions:

    • Modified PDMS formulations, particularly those incorporating PEG, are promising for developing controlled-release tablet coatings.
    • PEG acts as an effective channeling agent, enabling tunable zero-order drug release profiles.
    • Further optimization of PEG concentration can achieve sustained drug release over extended periods.