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Related Experiment Videos

Neonatal herpes simplex infection.

David W Kimberlin1

  • 1Division of Pediatric Infectious Diseases, The University of Alabama at Birmingham, Birmingham, Alabama 35233, USA. dkimberlin@peds.uab.edu

Clinical Microbiology Reviews
|January 17, 2004
PubMed
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Neonatal herpes simplex virus (HSV) disease management has significantly improved outcomes, with decreased mortality and better development in affected infants. Increased awareness of neonatal HSV infection is crucial for further progress.

Area of Science:

  • Neonatal infectious diseases
  • Virology
  • Pediatric neurology

Background:

  • Neonatal herpes simplex virus (HSV) infection poses a severe threat to newborns.
  • Significant advancements in diagnosis and management have been made over the last 30 years.
  • Despite progress, neonatal HSV disease remains a critical concern.

Purpose of the Study:

  • To review the advances in the diagnosis and management of neonatal HSV disease.
  • To highlight the impact of these advances on mortality and morbidity.
  • To emphasize the importance of increased awareness and understanding of neonatal HSV.

Main Methods:

  • Review of historical data on neonatal HSV disease outcomes.
  • Analysis of changes in mortality and morbidity rates over three decades.

Related Experiment Videos

  • Discussion of the biology and natural history of HSV in pregnant women and neonates.

    • Main Results:

    • Mortality for disseminated neonatal HSV disease decreased from 85% to 29%.
    • Mortality for central nervous system (CNS) neonatal HSV disease decreased from 50% to 4%.
    • Normal development at 1 year for disseminated disease increased from 50% to 83%; neurologic morbidity for CNS disease remained similar, but overall normal development improved due to better survival.

    Conclusions:

    • Advances in diagnosis and management have substantially improved survival rates for neonatal HSV disease.
    • While neurologic morbidity in CNS disease persists, overall patient outcomes have improved.
    • Enhanced awareness and understanding of neonatal HSV infection are essential for further improving patient outcomes.