Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emergence of distinct Streptococcus pyogenes emm1 and emm12 lineages in China.

Nature microbiology·2026
Same author

The GFI1-FOXO1 axis regulates NK cell maturation and function.

Nature communications·2026
Same author

Fibroblasts as regulators of lung immunity, repair and fibrosis.

Nature reviews. Immunology·2026
Same author

NeuO-mediated O-acetylation of uropathogenic <i>Escherichia coli</i> K1 capsule enhances resistance to phage and neutrophil killing.

Journal of bacteriology·2026
Same author

Acquisition of toxin-encoding lysogenic bacteriophage elements enhances the virulence of pandemic <i>Streptococcus pyogenes</i> M1<sub>UK</sub>.

Infection and immunity·2026
Same author

Group A Streptococcus interacts with glycosaminoglycans via M proteins to modulate bacterial adherence in vitro.

The FEBS journal·2025

Related Experiment Video

Updated: Jul 3, 2026

Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

Current progress in developing mRNA-lipid nanoparticle vaccines against human bacterial pathogens.

Brody Pullinger1, Nichaela Harbison-Price1, Ismail Sebina2

  • 1Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.

Clinical Microbiology Reviews
|July 2, 2026
PubMed
Summary

Messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccines show promise against viruses and cancer. However, developing these advanced vaccines against bacterial pathogens faces unique challenges, requiring further research.

Keywords:
Streptococcus pyogenesgroup A streptococcuslipid nanoparticlemRNAvaccines

More Related Videos

Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing
08:55

Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing

Published on: January 20, 2023

Related Experiment Videos

Last Updated: Jul 3, 2026

Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing
08:55

Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing

Published on: January 20, 2023

Area of Science:

  • Vaccinology
  • Infectious Disease Research
  • Biotechnology

Background:

  • Messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccines have emerged as a significant advancement in vaccinology.
  • Recent studies since 2020 highlight their proven efficacy against viral infections and cancer.
  • Development of mRNA-LNP vaccines for bacterial pathogens remains limited due to specific challenges.

Purpose of the Study:

  • To review the challenges in developing mRNA-LNP vaccines against bacterial pathogens.
  • To outline the potential advantages of using the mRNA-LNP platform for bacterial vaccines.
  • To summarize the current progress in creating mRNA-LNP vaccines for bacterial infections.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of challenges specific to bacterial vaccine development.
  • Evaluation of the mRNA-LNP platform's applicability to bacterial targets.

Main Results:

  • Significant hurdles exist in adapting mRNA-LNP technology for bacterial vaccine applications.
  • The mRNA-LNP platform offers unique benefits for bacterial vaccine design.
  • Progress is being made, but substantial research is still needed.

Conclusions:

  • Overcoming bacterial vaccine-specific challenges is crucial for mRNA-LNP platform expansion.
  • Further investigation is required to fully realize the potential of mRNA-LNP vaccines against bacterial diseases.