Related Experiment Video

Updated: Apr 24, 2026

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
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The GFI1-FOXO1 axis regulates NK cell maturation and function

Qiutong Huang1,2,3,4, M Zeeshan Chaudhry5, James Dight1

  • 1The University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia.

Nature Communications
|April 22, 2026
PubMed
Summary

Growth factor independence 1 (GFI1) is an epigenetic regulator essential for natural killer (NK) cell differentiation. It balances key transcription factors, promoting NK cell maturation and anti-tumour activity by interacting with FOXO1.

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